I just ran into this little issue when testing a small JavaScript, where Internet Explorer came up with this annoying little pop-up on the bottom of the page every time I wanted to test a new change in the code:

Unless I clicked “Allow blocked content” every single time, JavaScript was simply disabled.
That’s just no good…
So, it was time to kill off this annoyance once and for all!
First, I right-clicked an empty area on the light blue top bar in Internet Explorer to bring up this menu, and enabled the Menu bar:

Then, I clicked on Tools on the menu bar that I just enabled, then selected Internet Options:

Clicked the Advanced tab, scrolled down the list until I found the Security header.
Then simply ticked the box that says Allow active content to run in files on My Computer*:

Then, I simply restarted Internet Explorer and the problem was solved!